Altered RNA splicing contributes to skeletal muscle pathology in Kennedy disease knock-in mice
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چکیده
منابع مشابه
Altered RNA splicing contributes to skeletal muscle pathology in Kennedy disease knock-in mice.
Here, we used a mouse model of Kennedy disease, a degenerative disorder caused by an expanded CAG repeat in the androgen receptor (AR) gene, to explore pathways leading to cellular dysfunction. We demonstrate that male mice containing a targeted Ar allele with 113 CAG repeats (AR113Q mice) exhibit hormone- and glutamine length-dependent missplicing of Clcn1 RNA in skeletal muscle. Changes in RN...
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ژورنال
عنوان ژورنال: Disease Models & Mechanisms
سال: 2009
ISSN: 1754-8411,1754-8403
DOI: 10.1242/dmm.003301